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Because dogs are the masters of disguise when it comes to pain and illness, you may not notice the signs of lyme disease or you may simply think your dog is having an "off" day. You know your dog best and are her best advocate; if you notice she's not herself, give your vet a call. Before you do that though, check her skin and body thoroughly to see if you notice the telltale bullseye or a rash that could denote a tick bite.